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. 2016 Oct 22;5(12):1187–1199. doi: 10.1016/j.molmet.2016.10.004

Figure 4.

Figure 4

Peripherally restricted CB1R antagonism reduces body weight, hyperphagia, and adiposity in Magel2-null mice. Both JD5037 and SLV319 (3 mg/kg/day for 28 d) reduced body weight (A–D), and fat mass (E, G), without affecting lean body mass (F, H). These effects were associated with normalizing food intake (I, K), and serum leptin levels (J, L) in HFD-induced obese Magel2-null mice. Similar patterns of results were obtained both in male (left panels) and female (right panels) mice. Legend: Vehicle, V; JD5037, J; SLV319, S.; red arrow represents 1st day of treatment. Data represent the mean ± SEM from 5 to 10 mice per group. *P < 0.05 relative to STD-V of the same genotype; #P < 0.05 relative to HFD-V of the same genotype; &P < 0.05 relative to the same treatment group of the other genotype.