Figure 7.

Peripherally restricted CB₁R antagonism restores the energy profile in obese Magel2-null mice. Daily chronic treatment of HFD-induced obese Magel2-null mice and their littermate wild-type controls with JD5037 and SLV319 (3 mg/kg/day for 28 d) increases TEE (A, B), voluntary activity (C, D), FO (E, F), and CHO (G, H), as measured by indirect calorimetry. Almost similar patterns of results were obtained both in obese male (left panels) and female (right panels) mice. Legend: Vehicle, V; JD5037, J; SLV319, S. Data represent the mean ± SEM from 8 to 10 mice per group. *P < 0.05 relative to STD-V of the same genotype; ^#P < 0.05 relative to HFD-V of the same genotype; ^&P < 0.05 relative to the same treatment group of the other genotype.