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. 2016 Oct 13;5(12):1162–1174. doi: 10.1016/j.molmet.2016.10.001

Figure 3.

Figure 3

Lean GF mice are characterized by higher respiratory exchange ratio and energy loss in feces. (A) Respiratory exchange ratio in GF and SPF mice fed CD, PHFD, and LHFD. Left: $ GF PHFD vs. GF LHFD: p < 0.05; right: $ SPF PHFD vs. SPF LHFD: p < 0.05. CD-fed GF mice were different to HFD-fed mice at all time points unless otherwise labeled with ns. Different superscript letters indicate significant statistical differences (p < 0.05). Black bars above the x-axis indicate nocturnal phases. SPF CD: n = 9; SPF PHFD: n = 10; SPF LHFD: n = 10; GF CD: n = 8; GF PHFD: n = 9; GF LHFD: n = 10. Data are shown as means ± sd. (B) Fecal energy and (C) fat excretion in GF and SPF C57BL/6N mice (housed in groups) during the first and the last week of feeding. Data were adjusted for feces production as well as dietary energy or fat intake, respectively. SPF CD: n = 6; SPF PHFD: n = 6; SPF LHFD: n = 6; GF CD: n = 7; GF PHFD: n = 7; GF LHFD: n = 4. Linear regressions used for adjustment including both GF and SPF mice: Fecal energy contentadj. [kJ*g−1] = 13.0443 + 0.0273 * dietary energy intake − 0.8356 * feces production (adjusted r2 = 0.32, p < 0.001). Fecal fat contentadj. [%] = −0.0723 + 0.0261 * dietary fat intake − 0.3704 * feces production (adjusted r2 = 0.52, p < 0.001). ns: not significant.