Table 4.

Conditional analysis of selected regions adjusting for the lead common variant identified by previous genome-wide association studies

Metabolite	Region	Type	GWAS Lead SNV	Discovery (AA)		Replication (EA)
				P unadjusted	P adjusted	P unadjusted	P adjusted
Indolelactate*	CCBL1	Gene	rs15676	1.3 × 10−20	1.1 × 10−20	2.1 × 10−6	4.1 × 10−6
N-acetyl-1-methylhistidine	Chr2: 73744005–73748004 (NAT8)	Window	rs13538	1.6 × 10−15	0.005	4.0 × 10−4	0.2
N-acetyl-1-methylhistidine	Chr2: 73614005–73618004 (NAT8)	Window	rs13538	6.2 × 10−11	0.9	0.005	0.8
Asparagine*	AGA	Gene	rs4690522	6.8 × 10−10	9.1 × 10−10	1.5 × 10−5	6.0 × 10−8
Dimethlyglycine*	DMGDH	Gene	rs248386	1.1 × 10−26	4.3 × 10−27	4.4 × 10−11	4.5 × 10−10
Alpha-hydroxyisovalerate*	HAO2	Gene	rs12141041	1.5 × 10−5	3.0 × 10−5	9.3 × 10−5	2.0 × 10−4
Proline*	PRODH	Gene	rs2540641	1.4 × 10−26	1.7 × 10−26	1.3 × 10−12	1.2 × 10−13

*Unadjusted results may differ from main analysis because only individuals with both exome sequencing and whole genome sequencing were included in the conditional analysis. SNV single nucleotide variant