Table 1.

Description of publications using optogenetics to query basic fear-related circuitries.

Publication	Investigated Circuitry
Morozov et al. (2011)	Inputs from TeA → LA receive feed forward inhibition from ITC while ACC → LA inputs do not.
Sparta et al. (2014)	BLA→ EC projections are necessary for the acquisition but not the expression of conditioned fear.
Kwon et al. (2014)	Activation of MGm→ BLA and AuV→ BLA projections is sufficient to act as a conditioned CS.
Tye et al. (2011)	Activation/inhibition of BLA→ CeA terminals is sufficient for anxiolysis/anxiogenesis, but activation of cell bodies is not.
Namburi et al. (2015)	Synaptic strengthening of BLA→ CeA projections after fear learning and of BLA→ NAc projections after appetitive training.
Do-Monte et a. (2015)	IL activity in rats is necessary for encoding but not retrieval of extinction memory.
Kim et al. (2016)	Inhibition/activation of IL activity in mice is sufficient for enhancement/blocking of extinction retrieval.
Ciocchi et al. (2010)	Activation of CeM is sufficient to produce spontaneous freezing.
Kwon et al. (2015)	Inputs from LAdl to ITCd generate feed-forward inhibition of CeL. ITCd receives additional GABAergic inputs to gate its activity during sub-threshold training
Stuber et al. (2011)	Activation of BLA→ NAc is sufficient to support ICSS.
Kim et al. (2013)	Activation/inhibition of BLA→ adBNST projections is anxiolytic/anxiogenic.