Table 2.
Description of publications using cell-type specific methodologies to query fear related circuitry.
| Publication | Investigated Circuitry |
|---|---|
|
| |
| Kravitz et al. (2012) | Optical activation of D1 direct/D2 indirect pathway supports place preference/place avoidance. |
| Ciocchi et al. (2010) and Haubensak et al. (2010) | Identified PKCd + population as decreasing firing during fear conditioning, relieving inhibition of PAG projecting CeM population, supporting fear expression. |
| Botta et al. (2015) | Activity in CeL PKCd population supports fear generalization and tonic activity in these neurons is dynamically regulated by extrasyaptic α5-GABAAR. |
| Cai et al. (2014) | Activation of CeL PKCd neurons is acutely anxiolytic. |
| Halhong Li et al. (2013) | SOM+ neurons of CeL represent opposing population to PKCd population; increasing activity with fear learning. Activity in these neurons is sufficient to support spontaneous freezing. |
| Andero et al. (2014) | CeA Tac2 neurons are necessary for fear acquisition. Antagonism of Tac2 receptor is sufficient to block fear consolidation. |
| Han et al. (2015) | PBN→ CeA transmits US information. Inhibition of PBN CGRP neurons blocks FC while activation is sufficient for generation of fear responses. |
| Likhtik et al. (2008) | Ablation of ITCm is sufficient to impair expression of extinction. |
| Wolff et al. (2014) | PV and SOM neurons in the BLA create disinhibitory circuit gating cortical and thalamic inputs to principal neurons. |
| Jasnow et al. (2013) | Activation of BLA Thy1-ChR2 population is sufficient to block fear acquisition and enhance fear extinction. |
| Knobloch et al. (2012) | Activation of hypothalamic OT fibers in CeL is sufficient to increase feed-forward inhibition of CeM in an OT dependent manner. |
| Lee H et al. (2014) | ESR1 neurons in the VMHvl generate investigative/mounting/attack behaviors in an intensity/recruitment dependent manner. |
| Kunwar et al. (2015) | SF1 neurons of the VMHdm/c generate freezing/escape behaviors in an intensity/recruitment dependent manner. |
| Huff et al. (2016) | Activation of BLA→ vHPC projections is sufficient to support aversive learning, but not contextual learning. |