Table 1.
Altered significantly mRNA content (p ≤ 0.05) after myocardial infarction.
| Gene ID | mRNA description | OC × SH | AB × SH | OC × AB |
|---|---|---|---|---|
| Log2 fold | Log2 fold | Log2 fold | ||
| EXTRACELLULAR MATRIX | ||||
| 84032 | COL3A1 | 1.60* | 1.65* | unaltered |
| 29393 | COL1A1 | 3.10*** | 3.90*** | 1.25*** |
| 59086 | TGF1B | unaltered | 1.58* | 1.42* |
| 116640 | TNC | 3.32*** | 6.68*** | 2.01* |
| 81687 | MMP9 | 2.41*** | unaltered | 2.03*** |
| INFLAMMATION | ||||
| 24498 | IL6 | 1.07*** | 1.18* | unaltered |
| 25625 | TNFRSFLA | 1.41* | unaltered | −1.05* |
| 24835 | TNFa | 1.13* | 1.83*** | unaltered |
| APOPTOSIS | ||||
| 24887 | BAX | 1.11* | 1.31* | unaltered |
| 24842 | TP53 | 1.11* | 1.82*** | unaltered |
| 81694 | MAPK14 | −1.07*** | unaltered | 1.21* |
| 116590 | MAPK1 | −1.09*** | 1.92*** | unaltered |
| OXIDATIVE STRESS | ||||
| 29323 | GPX4 | 1.35* | 2.28* | unaltered |
| 24248 | CAT | −1.04*** | 2.29*** | unaltered |
| 311427 | HSPA12B | 1.34* | unaltered | unaltered |
| 24786 | SOD1 | −1.05*** | −1.23* | unaltered |
| ANGIOGENESIS | ||||
| 11651 | AKT1 | 1.65*** | 2.26* | 1.37*** |
| 83785 | VEGFA | −1.50*** | −1.51* | unaltered |
| HYPERTROPHY | ||||
| 24310 | ECA | −1.06* | 1.13* | unaltered |
| 302668 | ECA2 | unaltered | 1.58* | 1.99*** |
| 24323 | EDN1 | 1.78* | 2.22*** | unaltered |
| 24602 | NPPA | 4.49* | 1.91* | unaltered |
| 25105 | NPPB | 2.18*** | 2.22* | unaltered |
| 24482 | IGF1 | unaltered | 1.68* | 1.68* |
| 24681 | PRKCG | unaltered | unaltered | −1.23*** |
| 24680 | PRKCA | 1.13* | 2.29*** | unaltered |
| 308965 | CHP2 | −1.78* | unaltered | 1.72* |
| 24180 | AGTR1A | −1.20*** | 1.70*** | unaltered |
| 361400 | NFATC3 | 1.10*** | 2.23*** | unaltered |
| CELL SURVIVAL | ||||
| 29556 | MYH6 | −1.52* | 2.73* | unaltered |
| 29557 | MYH7 | 1.60*** | unaltered | unaltered |
| CALCIUM SIGNALING | ||||
| 689560 | RYR2 | −1.30* | 2.30*** | unaltered |
| 29693 | ATP2A2 | −1.07*** | 1.92* | 2.05* |
| 29209 | CASQ2 | −1.05*** | 1.94*** | 2.04*** |
| 64672 | PLN | 1.11*** | 3.36*** | 6.16*** |
| 29715 | SLC8A1 | 1.38*** | 3.29*** | 2.39* |
| METABOLISM | ||||
| 25058 | HK1 | 1.59*** | 2.75*** | 1.72* |
| 54315 | UCP2 | 1.56*** | 2.36* | 1.51* |
| 24778 | SLC2A1 | 1.09*** | 1.90* | 1.75*** |
| 65152 | PFKM | −1.54*** | 1.19* | 1.80*** |
| 691001 | NDUFA3 | 1.13*** | 2.27*** | unaltered |
| 363521 | TAZ | 1.10*** | 1.59* | unaltered |
Gene ID refers to NCBI database numbers. OC × SH refers to Occlusion group vs. Sham animals, AB × SH refers to Ablation group compared to Sham animals, OC × AB refers to the comparison of both MI protocols.
*
p ≤ 0.05,
***
p ≤ 0.001, unaltered refers to p > 0.05. More details are provided in Methods Section.