Figure 1. Expression of let7i microRNA in ischemic stroke.

(A) Relative expression of let7i in patients with acute ischemic stroke (n = 106) compared to vascular risk controls (n = 106). Let7i decreased in leukocytes of patients with acute ischemic stroke compared to controls (fold change = −1.70, p = 0.00001). A decrease in level of let7i correlated modestly with (B) an increase in NIHSS score at admission, (C) an increase in infarct volume (log₁₀ mm³), and (D) an increase in plasma MMP9 (log₁₀ pg/mL) in patients with acute ischemic stroke. CT = cycle threshold; NIHSS = NIH Stroke Scale; RQ = relative quantification.