Fig. 3.

Normal adjacent pancreas is more vascularised in PDAC. A, B: Histopathological image of normal pancreas adjacent to PDAC showing higher vascular density, as identified by CD31 immuno-histochemistry. Scale Bar: 100 μm. C, D: The micro-vascular density (MVD, C) was measured by number of vessels/mm². The total vascular area (TVA, D) was measured by area occupied by vessels per 1000 units of area using automated Ariol™ analysis for the normal adjacent areas in PDAC and normal pancreas. The summary data are shown in the form of box (median and interquartile ranges) and whisker (95% range) graphs. Each data-point is a selected area analysed. Statistical analysis by Mann-Whitney U test. **P < 0.01.