Table 4.
Genotype frequencies of TLR2 and TLR6 gene SNPs with overall controls according to the daily quantity of cigarettes
| Gene | SNP | Allele | Nonsmokers | ≥20 cigarettes | OR | 95% CI | χ2 | P-value |
|---|---|---|---|---|---|---|---|---|
| Patients smoking ≥20 cigarettes/day | ||||||||
| TLR2 | rs3804100 | Total | 122 | 98 | – | – | – | – |
| TT | 3 (0.02) | 1 (0.01) | Ref | – | – | – | ||
| TC | 19 (0.16) | 18 (0.18) | 2.84 | 0.2702–29.8978 | 0.8119 | 0.3676 | ||
| CC | 100 (0.82) | 79 (0.81) | 2.37 | 0.2418–23.2255 | 0.5822 | 0.4455 | ||
| TC + CC | 119 (0.98) | 97 (0.99) | 2.45 | 0.2504–23.8847 | 0.6301 | 0.4273 | ||
| T | 25 (0.10) | 20 (0.10) | Ref | – | – | – | ||
| C | 219 (0.90) | 176 (0.90) | 1.00 | 0.5401–1.8685 | 0.0002 | 0.9885 | ||
| rs3804099 | Total | 115 | 83 | – | – | – | – | |
| CC | 22 (0.19) | 23 (0.28) | Ref | – | – | – | ||
| CT | 52 (0.45) | 35 (0.42) | 0.64 | 0.3119–1.3290 | 1.4256 | 0.2325 | ||
| TT | 41 (0.36) | 25 (0.30) | 0.58 | 0.2707–1.2565 | 1.9088 | 0.1671 | ||
| CT + TT | 93 (0.81) | 60 (0.72) | 0.62 | 0.3162–1.2043 | 2.0209 | 0.1551 | ||
| C | 96 (0.42) | 81 (0.49) | Ref | – | – | – | ||
| T | 134 (0.58) | 85 (0.51) | 0.75 | 0.5031–1.1234 | 1.9419 | 0.1635 | ||
| TLR6 | rs3796508 | Total | 118 | 97 | – | – | – | – |
| GG | 115 (0.97) | 96 (0.99) | Ref | – | – | – | ||
| GA | 3 (0.03) | 1 (0.01) | 0.40 | 0.0409–3.9014 | 0.6661 | 0.4144 | ||
| AA | 0 (0.00) | 0 (0.00) | – | – | – | – | ||
| GA + AA | 3 (0.03) | 1 (0.01) | 0.40 | 0.0409–3.9014 | 0.6661 | 0.4144 | ||
| G | 233 (0.99) | 193 (0.99) | Ref | – | – | – | ||
| A | 3 (0.01) | 1 (0.01) | 0.40 | 0.0415–3.9000 | 0.6598 | 0.4166 | ||
| rs5743810 | Total | 97 | 89 | – | – | – | – | |
| CC | 11 (0.11) | 2 (0.02) | Ref | – | – | – | ||
| CT | 27 (0.28) | 23 (0.26) | 4.69 | 0.9402–23.3463 | 4.0403 | 0.0444* | ||
| TT | 59 (0.61) | 64 (0.72) | 5.97 | 1.2693–28.0427 | 6.3218 | 0.0119* | ||
| CT + TT | 86 (0.89) | 87 (0.98) | 5.56 | 1.1978–25.8463 | 5.9034 | 0.0151* | ||
| C | 49 (0.25) | 27 (0.15) | Ref | – | – | – | ||
| T | 145 (0.75) | 151 (0.85) | 1.89 | 1.1212–3.1856 | 5.8126 | 0.0159* | ||
| Patients smoking <20 cigarettes/day | ||||||||
| TLR2 | rs3804100 | Total | 122 | 58 | – | – | – | – |
| TT | 3 (0.02) | 3 (0.05) | Ref | – | – | – | ||
| TC | 19 (0.16) | 9 (0.16) | 0.47 | 0.0794–2.8260 | 0.6899 | 0.4062 | ||
| CC | 100 (0.82) | 46 (0.79) | 0.46 | 0.0894–2.3666 | 0.9023 | 0.3422 | ||
| TC + CC | 119 (0.98) | 55 (0.95) | 0.46 | 0.0904–2.3635 | 0.8982 | 0.3433 | ||
| T | 25 (0.10) | 15 (0.13) | Ref | – | – | – | ||
| C | 219 (0.90) | 101 (0.87) | 0.77 | 0.3886–1.5205 | 0.5739 | 0.4487 | ||
| rs3804099 | Total | 115 | 53 | – | – | – | – | |
| CC | 22 (0.19) | 12 (0.23) | Ref | – | – | – | ||
| CT | 52 (0.45) | 27 (0.51) | 0.95 | 0.4097–2.2120 | 0.0131 | 0.9088 | ||
| TT | 41 (0.36) | 14 (0.26) | 0.63 | 0.2473–1.5849 | 0.9837 | 0.3213 | ||
| CT + TT | 93 (0.81) | 41 (0.77) | 0.81 | 0.3655–1.7873 | 0.2771 | 0.5986 | ||
| C | 96 (0.42) | 51 (0.48) | Ref | – | – | – | ||
| T | 134 (0.58) | 55 (0.52) | 0.77 | 0.4865–1.2269 | 1.1979 | 0.2737 | ||
| TLR6 | rs3796508 | Total | 118 | 57 | – | – | – | – |
| GG | 115 (0.97) | 54 (0.95) | Ref | – | – | – | ||
| GA | 3 (0.03) | 2 (0.04) | 1.42 | 0.2304–8.7468 | 0.1441 | 0.7042 | ||
| AA | 0 (0.00) | 1 (0.02) | – | – | – | – | ||
| GA + AA | 3 (0.03) | 3 (0.05) | 2.13 | 0.4161–10.8984 | 0.8593 | 0.3539 | ||
| G | 233 (0.99) | 110 (0.96) | Ref | – | – | – | ||
| A | 3 (0.01) | 4 (0.04) | 2.82 | 0.6214–12.8365 | 1.9636 | 0.1611 | ||
| rs5743810 | Total | 97 | 53 | – | – | – | – | |
| CC | 11 (0.11) | 1 (0.02) | Ref | – | – | – | ||
| CT | 27 (0.28) | 16 (0.30) | 6.52 | 0.7681–55.3212 | 3.6631 | 0.0556 | ||
| TT | 59 (0.61) | 36 (0.68) | 6.71 | 0.8313–54.1942 | 4.1157 | 0.0425* | ||
| CT + TT | 86 (0.89) | 52 (0.98) | 6.65 | 0.8343–53.0215 | 4.1616 | 0.0414* | ||
| C | 49 (0.25) | 18 (0.17) | Ref | – | – | – | ||
| T | 145 (0.75) | 88 (0.83) | 1.65 | 0.9052–3.0153 | 2.7071 | 0.0999 | ||
Notes:
*
P<0.05,
**
P<0.01. Values in parentheses are frequencies. Values in bold represent significant results.
Abbreviations: CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; TLR, toll-like receptor; Ref, reference.