Table 3.
Univariate and multivariate analyses of factors in relation to recurrence-free survival using the Cox proportional hazards model (n=120)
| Variables | RFS
|
|
|---|---|---|
| HR (95% CI) | P-values | |
| Univariate analysis | ||
| Age (≤60 vs >60) | 1.066 (0.615–1.847) | 0.820 |
| Smoking (no vs yes) | 0.783 (0.421–1.458) | 0.441 |
| Drinking (no vs yes) | 0.929 (0.536–1.611) | 0.793 |
| Tumor subsite (supraglottic/glottic/subglottic) | 0.712 (0.214–2.375) 0.597 (0.180–1.982) |
0.640 |
| T stage (T1 + T2 vs T3 + T4) | 1.127 (0.650–1.955) | 0.670 |
| N stage (N0 vs N1–N3) | 1.117 (0.624–1.999) | 0.710 |
| TNM stages (I + II vs III + IV)a | 1.240 (0.679–2.265) | 0.485 |
| Pathological type (highly/moderately/poorly) | 0.656 (0.232–1.853) 0.743 (0.313–1.765) |
0.721 |
| NLR (low vs high) | 1.921 (1.107–3.335) | 0.020 |
| PLR (low vs high) | 2.698 (1.475–4.938) | 0.001 |
| TILs density (low vs high) | 0.456 (0.260–0.802) | 0.006 |
| Multivariate analysis | ||
| PLR (low vs high) | 2.622 (1.431–4.804) | 0.002 |
| TILs density (low vs high) | 0.473 (0.269–0.832) | 0.009 |
Note:
a
According to the 7th American Joint Committee on Cancer staging system.
Abbreviations: NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; TILs, tumor infiltrating lymphocytes; RFS, recurrence-free survival; HR, hazard ratio; CI, confidence interval.