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. 2016 Nov 21;12:1763–1776. doi: 10.2147/TCRM.S112685

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© 2016 Beltrametti et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Circadian rhythm of (A) pain measures in healthy subjects and of (B) stiffness, (C) pain levels, and (D) functional disabilities in rheumatoid arthritis patients.

Notes: Values are expressed as the mean and standard error of mean. Horizontal bars starting at 21.00 (9 pm) indicate sleeping time. Vertical dotted lines show the peak or minimum value for the respective parameter. Republished with permission of John Wiley and Sons Inc, from Straub RH, Cutolo M. Circadian rhythms in rheumatoid arthritis: implications for pathophysiology and therapeutic management. Arthritis Rheum. 2007;56(2):399–408; permission conveyed through Copyright Clearance Center, Inc.15