Table 2.

Acetaminophen

Medication	Indication	Dosage Range	Clinical Pearls
Acetaminophen  (APAP; Tylenol)	Mild-to-  moderate  pain	Starting dose for older  adults is same as for  younger adults Consider dose reduction in  older adults with risk  factors for  acetaminophen-related  toxicities, for example,  frailty, alcohol use (≥3  drinks per day), existing  liver insufficiency 325-500 mg every 4 h or  500-1000 mg every 6 h Maximum daily dose: per  McNeil Consumer  Healthcare, 3000 mg/d;  Health care professionals  may still prescribe  4000 mg/d and are  advised to use their own  discretion and clinical  judgment	Consider all sources of acetaminophen (prescription and over the counter) and all routes of administration Monitoring: check liver function, signs and symptoms of liver injury