Table 3.
CT characteristics of patients with an EGFR mutant tumor versus patients with an ALK positive tumor
| Characteristic | EGFR+ | ALK+ | P-value |
|---|---|---|---|
| Location, N (%) | |||
| 1 | 12 (18.2) | 14 (34.1) | |
| 2 | 54 (81.8) | 27 (65.9) | 0.069 |
| Size, N (%) | |||
| 1 | 6 (9.1) | 8 (19.5) | |
| 2 | 24 (36.4) | 13 (31.7) | |
| 3 | 31 (46.9) | 7 (17.1) | |
| 4 | 5 (7.6) | 9 (21.9) | |
| 5 | 0 (0.0) | 4 (9.8) | < 0.001 |
| Pleural attachment, N (%) | |||
| 1 | 22 (33.3) | 9 (22.0) | |
| 2 | 27 (40.9) | 14 (34.1) | |
| 3 | 17 (25.8) | 18 (43.9) | 0.149 |
| Pleural retraction, N (%) | |||
| 1 | 2 (3.0) | 5 (12.2) | |
| 2 | 64 (97.0) | 36 (87.8) | 0.104 |
| Lobulation, N (%) | |||
| 1 | 3 (4.6) | 3 (7.3) | |
| 2 | 29 (43.9) | 16 (39.0) | |
| 3 | 34 (51.5) | 22 (53.7) | 0.764 |
| Spiculation, N (%) | |||
| 1 | 12 (18.2) | 9 (21.9) | |
| 2 | 22 (33.3) | 20 (48.8) | |
| 3 | 32 (48.5) | 12 (29.3) | 0.141 |
| Concavity, N (%) | |||
| 1 | 15 (22.7) | 16 (39.0) | |
| 2 | 51 (77.3) | 25 (61.0) | 0.083 |
| GGO, N (%) | |||
| 1 | 44 (66.7) | 39 (95.1) | |
| 2 | 22 (33.3) | 2 (4.9) | 0.001 |
| Airbronchogram, N (%) | |||
| 1 | 22 (33.3) | 20 (48.8) | |
| 2 | 29 (43.9) | 18 (43.9) | |
| 3 | 15 (22.7) | 3 (7.3) | 0.073 |
| Bubble-like lucency, N (%) | |||
| 1 | 43 (65.2) | 35 (85.4) | |
| 2 | 17 (25.8) | 3 (7.3) | |
| 3 | 6 (9.1) | 3 (7.3) | 0.048 |
| Necrosis, N (%) | |||
| 1 | 66 (100.0) | 38 (92.7) | |
| 2 | 0 | 3 (7.3) | -- |
| Calcification, N (%) | |||
| 1 | 56 (84.8) | 33 (80.5) | |
| 2 | 10 (15.2) | 8 (19.5) | 0.601 |
| Obstructive changes, N (%) | |||
| 1 | 35 (53.0) | 27 (65.9) | |
| 2 | 30 (45.5) | 12 (29.3) | |
| 3 | 1 (1.5) | 2 (4.9) | 0.160 |
| Involved vessel pattern, N (%) | |||
| 1 | 35 (53.0) | 24 (58.5) | |
| 2 | 6 (9.1) | 6 (14.6) | |
| 3 | 16 (24.2) | 9 (21.9) | |
| NA | 9 (13.6) | 2 (4.9) | 0.455 |
| Nodules in the same lobe, N (%) | |||
| 1 | 57 (86.4) | 31 (75.6) | |
| 2 | 9 (13.6) | 10 (24.4) | 0.196 |
| Nodules in other lobes, N (%) | |||
| 1 | 49 (74.2) | 35 (85.4) | |
| 2 | 17 (25.8) | 6 (14.6) | 0.228 |
| Lymphadenopathy, N (%) | |||
| 1 | 50 (75.8) | 18 (43.9) | |
| 2 | 8 (12.1) | 5 (12.2) | |
| 3 | 8 (12.1) | 18 (43.9) | 0.001 |
| Pleural nodules, N (%) | |||
| 1 | 56 (84.8) | 35 (85.4) | |
| 2 | 10 (15.2) | 6 (14.6) | 0.999 |
| Mean longest dimension (cm), (SD) | 3.38 (1.15) | 3.92 (2.06) | 0.085 |
| Mean largest short dimension (cm), (SD) | 2.60 (0.85) | 2.97 (1.56) | 0.121 |
| Mean CT value pre-contrast (HU), (SD) | 27.66 (9.95) | 27.73 (11.39) | 0.974 |
| Mean CT value post-contrast (HU), (SD) | 70.26 (18.64) | 64.76 (22.15) | 0.203 |
| Mean contrast enhancement (HU), (SD) | 42.30 (18.51) | 37.36 (15.99) | 0.188 |
| Mean TDR, (SD) | 0.21 (0.24) | 0.09 (0.09) | 0.005 |
Abbreviations: TDR, tumor shadow disappearance rate; GGO, ground-glass opacity
Bolded values indicate a statistically significant result