Fig. 4.

CTC–substrate interaction model. The CTC is modeled as a rigid sphere. Receptors are modeled as strings randomly distributed on the surface of the CTC. Each receptor has a length of r₀, forming a capture zone with a radius of r₀. When ligands, which are modeled as an array of points on the device surface, are located within the capture zone, it is possible that a ligand–receptor is formulated. The ligand–receptor bond is considered as a spring. C.B., Korn, U.S. Schwarz, Dynamic states of cells adhering in shear flow: from slipping to rolling. Phys. Rev. E 77(4) (2008) 041904. Reproduced with a permission of American Physical Society.