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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Circ Cardiovasc Interv. 2016 Oct;9(10):e004058. doi: 10.1161/CIRCINTERVENTIONS.116.004058

Figure 1.

Figure 1

MI Model and Therapeutic Groups. A, Infarct generation by selective obtuse marginal ligation and injection with saline (MI control), guest-host hydrogel (GH), or dual-crosslinking hydrogel (DC) which were longitudinally assessed by MRI. B, GH hydrogels were composed of adamantane modified hyaluronic acid (Ad-HA, blue) and cyclodextrin modified hyaluronic acid (CD-HA, red) which form physical associations (purple). C, DC hydrogels were composed of thiolated Ad-HA (Ad-HA-SH) and methacrylated CD-HA (CD-MeHA), and resulted in additional covalent crosslinks (green). D, Both GH and DC hydrogels were injected into the infarcted region. E, DC hydrogel elastic moduli over time (mean±SD; n = 6; *P < 0.01 relative to day 0). GH moduli are excluded, due to swelling which prevented reliable rheological testing over time. F, Hydrogel degradation (mean±SD with error bars for all points (not visible for DC); n = 5; *P < 0.05 relative to DC for all timepoints beyond day 1).