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. 2015 Sep 17;4(12):1798–1808. doi: 10.1002/cam4.541

Figure 3.

Figure 3

Modulation of survival signaling by PME‐1 in colorectal cancer cells. The viability of HCA‐7 and CW‐2 cells transfected with Scr. or PME‐1 siRNA (for 72 h) was analyzed by CellTiter‐glo (CTG) (A) and WST‐1 (B) assays. Bars represent fold‐change values calculated over respective values for Scr. siRNA‐transfected cells (n = 3). Western blot analysis of protein lysates from siRNA‐transfected HCA‐7 (C) and CW‐2 (D) cells, using antibodies to phosphorylated forms of AKT and ERK. The phosphoprotein expression normalized with GAPDH (loading control) is shown as fold‐change values over Scr. siRNA‐transfected cells (n = 3). *P = 0.003 by Student's paired t‐test.