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. 2016 Nov 21;11:6207–6216. doi: 10.2147/IJN.S110274

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© 2016 Coriat et al. This work is published and licensed by Dove Medical Press Limited

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Relationship between DTS-108, SN-38, or SN-38G dose and exposure.

Notes: Relationship between DTS-108 dose exposure and DTS-108 C_max (A), SN-38 C_max (B), SN-38G C_max (C), DTS-108 AUC_inf (D), SN-38 AUC_inf (E), or SN-38G AUC_inf (F).

Abbreviations: SN-38, 7-ethyl-10-hydroxycampthotecin; SN-38G, SN-38 glucuronide; AUC_inf, area under the plasma concentration–time curve to infinity; C_max, peak of serum concentration.