Table 2.
Grades 3–4 and dose-limiting toxicities of treatment with DTS-108 (n=42)
| Dose (mg/m2) | Number of patients | Neutropenia
|
Other toxicities
|
|||
|---|---|---|---|---|---|---|
| Grades 3–4 | All grades | Grades 1–2 | Grades 3–4 | Type of toxicity and grade | ||
| 3 | 1 | – | – | – | – | – |
| 6 | 1 | – | – | – | – | – |
| 12 | 1 | – | – | – | – | – |
| 24 | 1 | – | – | – | – | – |
| 32 | 3 | – | – | 1 | – | Respiratory and thoracic disorder (UR) |
| 1 | – | Hyperbilirubinemia (UR) | ||||
| 42 | 3 | – | – | 1 | – | Retroperitoneal hematoma (UR) |
| 56 | 3 | – | – | 1 | – | Acute pancreatitis (UR) |
| 1 | – | Hyperbilirubinemia (UR) | ||||
| 75 | 3 | – | 1 | – | – | – |
| 100 | 3 | – | 1 | 1 | – | Complete left lung atelectasy (UR) |
| 133 | 4 | – | 3 | 1 | – | Hyperbilirubinemia (UR) |
| 177 | 3 | – | 1 | 1 | – | Vomiting (R), diarrhea (R), and nausea (R) |
| 236 | 4 | 1 | 1 | 1 | – | Edema of lower limb (UR) |
| – | 1 | Vomiting (R) and diarrhea (R) | ||||
| 1 | – | Vomiting (R) | ||||
| 313 | 6 | 4 | 6 | – | 1 | Diarrhea (R) |
| 1 | 1 | Hyperbilirubinemia (UR) | ||||
| 416 | 6 | 4 | 6 | 1 | – | Vomiting (UR), pyrexia (UR), and chills (R) |
Notes: UR, side effect considered as unrelated with DTS–108 infusion; R, side effect considered as probably related with DTS–108 infusion.