Table 3.
Treatment-emergent adverse events (drug-related toxicities) with total frequencies ≥10% after repeated dosing of DTS-108
| Adverse event | Number of patients with ≥1 adverse event | Total (%) |
|---|---|---|
| Nausea | 18 | 42.9 |
| Asthenia | 18 | 42.9 |
| Diarrhea | 17 | 40.5 |
| Vomiting | 14 | 33.3 |
| Anemia | 13 | 31.0 |
| Rash | 9 | 21.4 |
| Anorexia | 9 | 21.4 |
| Abdominal pain | 8 | 19.0 |
| Neutropenia | 8 | 19.0 |
| Alopecia | 8 | 19.0 |
| Lymphopenia | 7 | 16.7 |
| Pyrexia | 7 | 16.7 |
| Constipation | 6 | 14.3 |
| Leukopenia | 6 | 14.3 |
| Dyspnea | 9 | 12.4 |
| Ascites | 5 | 11.9 |
| Cough | 5 | 11.9 |
| Weight decreased >10% | 5 | 11.9 |
| Alanine aminotransferase elevation increased | 5 | 11.9 |
| Hypoalbuminemia | 5 | 11.9 |