Figure 1.

BChE activity reduction in patients with traumatic injury.

Notes: (A) Initial BChE activity measured at the hospital admission did not differ between healthy volunteers (control, filled gray), patients with an ISS≤3 (open gray), and those with ISS>3 (black, Kruskal–Wallis test followed by Dunn’s multiple comparisons test). Blood samples from patients without severe injury (ISS≤3, gray, B) and patients with traumatic injury (ISS>3, black, C) were tested for BChE activity changes over 5 h following hospital admission. Values represent relative change of BChE activity, normalized to the initial enzyme activity recorded on admission (A). Box plots in panels (A), (B), and (C) represent medians with 25% and 75% percentiles; error bars are minimum and maximum values. *P<0.05; **P<0.01; ***P<0.001. Observed BChE activity change has been tested using Friedman test for repeated measures followed by Dunn’s multiple comparisons test.

Abbreviations: BChE, butyrylcholinesterase; ISS, Injury Severity Score.