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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Oct 20;36(12):2412–2420. doi: 10.1161/ATVBAHA.116.308339

Figure 1. In vivo NADPH oxidase-mediated ROS in skeletal muscle of lean, overweight/mildly obese (Int), and obese subjects.

Figure 1

ROS was measured without superoxide dismutase (−SOD) in the perfusate, indicative of H2O2 produced endogenously. ROS detected with SOD added (+SOD) to the perfusate is indicative of endogenous superoxide in addition to H2O2. ROS were also measured in the absence (−Apo) and presence of apocynin (+Apo), an NADPH oxidase inhibitor. Values are mean±SEM for n = 13–15 subjects in each group. *P<0.05 vs. lean group. †P<0.05 vs. Int group. ‡Significant effect of apocynin (P<0.05). §Effect of SOD in obese significantly (P<0.05) greater than lean and Int groups.