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. Author manuscript; available in PMC: 2016 Nov 25.
Published in final edited form as: Microrna. 2012;1(1):70–79. doi: 10.2174/2211536611201010070

Fig. (1).

Fig. (1)

Local secondary structure of PUM and miR-221/222 binding sites.

PUM and miR-221/222 binding sites form a stem loop secondary structure by binding to each other on the 3’UTR of the p27Kip1 transcript. Binding of Pumilio is necessary to increase the accessibility of miRNA binding sites. The Pumilio and miR-221/222 recognition sites are shown in detail and the entire 3’ UTR, folded with RNAfold [101], is shown. The probability that a base is paired with other nucleotides is indicated with the color scheme shown.