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. Author manuscript; available in PMC: 2016 Nov 25.
Published in final edited form as: Arthritis Rheumatol. 2015 Sep 24;68(2):282–298. doi: 10.1002/art.39298

Table 1.

Outcomes framework*

The framework included the following 5 major outcomes:

  • Mortality

  • Health status
    • Symptoms (pain, stiffness, fatigue, sleep disturbance, swelling)
      • ○
        Measures include the Bath AS Disease Activity Index, pain scales, Short Form 36 subscales, and fatigue questionnaires
      • ○
        Surrogates include physical examination, AS Disease Activity Score, acute-phase reactants, and inflammation on imaging
    • Mental health (depression, anxiety) Measures include the Short Form 36 subscales
    • Quality of life (social interaction, sexual health, body image) Measures include the Short Form 36 subscales and AS Quality of Life questionnaire
  • Functional status
    • Physical function
      • ○
        Measures include the Bath AS Functional Index and Short Form 36 subscales
      • ○
        Surrogates include range of motion, the Bath AS Metrology Index, and structural damage on imaging
    • Work ability

  • Serious adverse events

  • AS-related morbidities

*

AS = ankylosing spondylitis.