Table 2.

Strength of recommendations in GRADE^*

Strength	Interpretation	Implications for clinicians	Implications for policymakers
Strongly in favor	Almost all informed patients would choose to receive the intervention	Should be accepted by most patients to whom it is offered	Should be adopted as policy
Conditionally in favor	Most informed patients would choose the intervention, but a sizable minority would not	Large role for education and shared decision-making	Requires stakeholder engagement and discussion
Conditionally against	Most informed patients would not choose the intervention, but a small minority would	Large role for education and shared decision-making	Requires stakeholder engagement and discussion
Strongly against	Most patients should not receive the intervention	Should not be offered to patients	Should be adopted as policy

^*GRADE = Grading of Recommendations, Assessment, Development and Evaluation.