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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Environ Mol Mutagen. 2016 Nov 1;57(9):656–667. doi: 10.1002/em.22059

Figure 4. Modulation of CYP1A activities in activated human T lymphocytes.

Figure 4

(A) Effect of HAA on CYP1 activity in activated human lymphocytes. CYP1 activity was measured by EROD activity in PMA/Iono activated human T lymphocytes after 24 h of treatment with 0.1% DMSO (Ctrl), HAA (10 μM) or 3-MC (1 μM). Data are expressed as the mean ± SD of seven independent experiments. (Student’s t-test, * P<0.05; **P<0.01, ***P<0.005 versus Ctrl). (B) Time-dependent effect of AαC on CYP1 activity in activated human T lymphocytes. CYP1 activity was measured by EROD activity in PMA/Iono activated human T lymphocytes after 0, 8, 24 and 72 h of treatment with 0.1% DMSO (Ctrl), AαC (10 μM) or 3-MC (1 μM). Data are expressed as the mean ± SD of four independent experiments (ANOVA followed by Tukey’s multiple comparison test, * P<0.05; **P<0.01, ***P<0.005 versus Ctrl). (C) Effect of different concentrations of AαC on CYP1 activity in activated human T lymphocytes. CYP1 activity was measured by EROD activity in PMA/Iono activated human T lymphocytes after 24 h of treatment with different concentrations of AαC (0.1 – 10 μM). Data are expressed as the mean ± SD of four independent experiments. (Student’s t-test, * P<0.05; **P<0.01, ***P<0.005 versus Ctrl).