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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Kidney Int. 2016 Aug 31;90(6):1262–1273. doi: 10.1016/j.kint.2016.06.037

Figure 3. Mesenchyme-specific deletion of Zeb2 with Six2-cre causes glomerulocystic kidney disease in adult mice.

Figure 3

(a) Macroscopic images of normal kidneys from a 7 weeks old control mouse (left panel) and pale and cystic kidneys (marked by asterisk) from a Zeb2flox/flox;Six2-cre+ homozygous mouse (right panel); n=5 in each group. (b) Histological images of kidneys from 7 weeks old control Zeb2+/+ mice and Zeb2flox/flox;Six2-cre+ cKO mice show large cysts in the renal cortex and outer medulla region in the cKO mice (n=3 in each group). Upper panels - 25x magnification; lower panels - 100x magnification with scale bars at 100 μm; g-glomerulus; cy-cyst.