Table 4.
Predictors of vaccination in children exposed to chronic glucocorticoid therapy
| Influenza Vaccine | Pneumococcal Polysaccharide Vaccine | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable |
Univariate OR
(95% CI) |
p |
Multivariate OR
(95% CI) |
p |
Univariate OR
(95% CI) |
p |
Multivariate OR
(95% CI) |
p |
| Age, years(baseline) | 0.87 (0.79, 0.97) | 0.01 | 0.87 (0.78, 0.96) | 0.008 | 0.91 (0.88, 0.95) | <0.001 | 0.94 (0.89, 0.99) | 0.02 |
| Follow up duration, months | 0.97. (0.91, 1.03) | 0.29 | 0.96 (0.89, 1.03) | 0.22 | 1.03 (1.00, 1.05) | 0.05 | 1.01 (0.98, 1.04) | 0.52 |
| Sex, Male | 1.82 (0.77, 4.32) | 0.18 | -- | -- | 1.18 (0.79, 1.76) | 0.43 | -- | -- |
| Race, Non-White | 0.89 (0.37, 2.10) | 0.78 | -- | -- | 2.78 (1.84, 4.20) | <0.001 | 1.72 (1.03, 2.89) | 0.04 |
| Hispanic Ethnicity | 0.75 (0.18, 3.21) | 0.70 | -- | -- | 0.73 (0.34, 1.58) | 0.43 | -- | -- |
| Non-Private Insurance | 0.71 (0.30, 1.69) | 0.44 | -- | -- | 2.20 (1.43, 3.39) | <0.001 | -- | -- |
| Height Z-Score, SD (baseline) |
0.81 (0.59, 1.12) | 0.21 | -- | -- | 0.96 (0.82, 1.13) | 0.62 | -- | -- |
| BMI Z-Score, SD (baseline) | 0.85 (0.63, 1.15) | 0.30 | -- | -- | 1.37 (1.14, 1.63) | 0.001 | -- | -- |
| In Network Care | N/A | N/A | N/A | N/A | 2.90 (1.87, 4.49) | <0.001 | 3.48 (1.91, 6.35) | <0.001 |
| GC Cumulative Dose Quartile |
||||||||
| 1 | Reference | -- | Reference | -- | Reference | Reference | -- | |
| 2 | 0.34 (0.08, 1.42) | 0.14 | -- | -- | 1.33 (0.63, 2.83) | 0.46 | 1.18 (0.50, 2.80) | 0.70 |
| 3 | 0.47 (0.12, 1.76) | 0.26 | -- | -- | 2.18 (1.08, 4.39) | 0.03 | 1.68 (0.75, 3.73) | 0.21 |
| 4 | 0.5 (0.14, 1.83) | 0.30 | -- | -- | 5.68 (2.97, 10.86) | <0.001 | 2.67 (1.24, 5.78) | 0.01 |
| Subspecialty | ||||||||
| Gastroenterology | Reference | -- | -- | -- | Reference | -- | Reference | -- |
| Nephrology | 1.33 (0.80, 2.21) | 0.27 | 1.14 (0.43, 3.01) | 0.79 | 30.37 (14.82, 62.24) | <0.001 | 28.72 (13.34, 61.84) | <0.001 |
| Rheumatology | 0.70 (0.36, 1.38) | 0.31 | 2.06 (0.38, 11.05) | 0.40 | 4.18 (1.77, 9.90) | 0.001 | 4.77 (1.92, 11.84) | 0.001 |
The multivariate model for influenza vaccine included: Age, Follow-Up Time, Specialty. The multivariate model for pneumococcal polysaccharide vaccine: Age, Follow-Up Time, Race, In Network, GC Cumulative Dose Quartile, Specialty