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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: J Neurochem. 2016 Nov 14;139(5):769–781. doi: 10.1111/jnc.13868

Figure 4. 3OHB treatment increases BDNF expression in cerebral cortical neurons in a MCT2-dependent manner.

Figure 4

A. Cortical neurons were incubated in medium containing 1 mM glucose and were then exposed to 8 mM 3OHB for 6 hours. Levels of mct2 mRNA were quantified (n =5 separate cultures). ***p<0.001. B. Cortical neurons (in medium containing 1 mM glucose) were pre-incubated with or without the MCT2 inhibitor AR-C155858 (1 µM) for 1 hour. The neurons were then treated with 8 mM 3OHB or vehicle control for 6 hours and were then processed for measurement of Bdnf mRNA levels (n = 4 separate cultures). *p<0.05.