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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Food Chem Toxicol. 2016 Oct 20;98(Pt B):107–118. doi: 10.1016/j.fct.2016.10.021

Figure 4.

Figure 4

JNK phosphorylation in liver cytosolic fraction and mitochondrial p-JNK translocation after APAP treatment in C57BL/6J and C57BL/6N mice. Animals were treated with 200 mg/kg APAP or saline as control. At 2 h and 8 h after APAP, cytosolic and mitochondrial fractions were subjected to western blotting for phosphorylated JNK, total JNK, porin and beta-actin (A and B). Densitometry was performed on these blots and the pJNK-to-JNK ratio, the pJNK-to-beta actin ratio and pJNK-to-Porin ratio was calculated for the different time points of C57BL/6J and C57BL/6N mice Data represent mean ± SE of n=3 animals per group. *p< 0.05 (compared with controls, t=0). #p< 0.05 (compared with C57BL/6J mice treated with APAP).