Table 1.
Characteristics of the CRIC study population with advanced CKD (defined as eGFR < 30 ml/min/1.73 m2) by category of systolic blood pressure (mm Hg) (N=1795)
| Characteristic | All (N=1795) | <120 N=627 |
120–140 N=601 |
>140 N=567 |
p value |
|---|---|---|---|---|---|
| Age, mean (SD), years | 59.9 (11.3) | 59.4 (11.9) | 59.8 (11.5) | 60.5 (10.1) | 0.2499 |
| Female (%) | 45.8 | 43.7 | 44.9 | 49.0 | 0.1587 |
| Race/ethnicity (%) | <.0001 | ||||
| Non-Hispanic White | 33.8 | 46.3 | 34.9 | 18.7 | |
| Non-Hispanic Black | 46.1 | 39.2 | 45.1 | 54.9 | |
| Hispanic | 16.7 | 11.0 | 16.3 | 23.5 | |
| Other | 3.4 | 3.5 | 3.7 | 3.0 | |
| Systolic blood pressure, mmHg | 131 (24) | 107 (10) | 129 (6) | 159 (16) | <.0001 |
| Diastolic blood pressure, mmHg | 69 (13) | 62 (10) | 70 (12) | 77 (14) | <.0001 |
| Pulse pressure, mmHg | 62 (20) | 46 (12) | 60 (13) | 82 (18) | <.0001 |
| Body Mass Index, kg/m2 | 32.5 (8.2) | 32.0 (8.0) | 33.2 (8.2) | 32.4 (8.3) | 0.0397 |
| Estimated Glomerular Filtration Rate, ml/min/1.73m2 | 26.2 (5.2) | 26.8 (5.0) | 26.3 (5.1) | 25.5 (5.4) | <.0001 |
| Proteinuria, median (IQR)mg/24 hour | 689 (163, 2480) | 263 (87, 946) | 699 (166, 2321) | 1953 (488, 4385) | <.0001 |
| Hypertension (%) | 95.0 | 90.0 | 95.5 | 100.0 | <.0001 |
| Number of blood pressure medication classes | 3.2 (1.5) | 3.0 (1.5) | 3.3 (1.4) | 3.3 (1.5) | 0.0002 |
| Diabetes (%) | 61.4 | 52.0 | 61.6 | 71.8 | <.0001 |
| Current Smoker (%) | 14.8 | 14.7 | 14.5 | 15.2 | 0.9431 |
| Prevalent atherosclerotic CVD (%) | 46.3 | 45.8 | 45.6 | 47.6 | 0.7452 |
| Prevalent heart failure (%) | 17.5 | 16.6 | 16.3 | 19.8 | 0.2288 |
| Statins (%) | 63.6 | 64.0 | 61.4 | 65.6 | 0.3530 |
| B-blockers (%) | 60.3 | 54.9 | 60.1 | 66.5 | 0.0002 |
| Calcium channel blockers (%) | 51.5 | 41.8 | 56.2 | 57.1 | <.0001 |
| ACE inhibitors/ARBS (%) | 71.1 | 77.8 | 71.6 | 63.1 | <.0001 |
| Diuretics (%) | 71.3 | 67.5 | 73.7 | 72.8 | 0.0213 |
| Alpha blockers and antagonists (%) | 29.6 | 26.8 | 31.1 | 31.2 | 0.1395 |