Table 3.
Distribution of tissue samples positive for P. gingivalis, T. denticola, T. forsythia and F. nucleatum gDNA by PCR.
| Group | Infection | Positive systemic tissue samples | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Heart | Aorta | Liver | Spleen | Kidney | Lung | Brain | ||
| n = 11 | n = 6 | n = 11 | n = 5 | n = 11 | n = 11 | n = 11 | ||
| TLR2−/− | Pg/Td/Tf/Fn | 8/4/5/1 | 5/1/3/0 | 1/0/0/0 | 0/0/0/0 | 9/2/0/11 | 4/3/0/4 | 0/0/0/0 |
| Control | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | |
|
| ||||||||
| n = 7 | n = 7 | n = 7 | n = 7 | n = 7 | n = 7 | n = 7 | ||
| TLR4−/− | Pg/Td/Tf/Fn | 7/2/0/2 | 6/3/0/5 | 0/2/1/1 | 0/0/0/0 | 1/1/0/0 | 3/0/1/1 | 0/0/0/0 |
| Control | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | |
Pg – P. gingivalis, Td – T. denticola, Tf – T. forsythia, Fn – F. nucleatum. The first value corresponds to the number of mice that tested positive for P. gingivalis genomic DNA, the second value to the number of mice that tested positive for T. denticola genomic DNA, the third value to the number of mice that tested positive for T. forsythia genomic DNA and the fourth value to the number of mice that tested positive for F. nucleatum genomic DNA. None of the sham-infected (control) mice were tested positive for any of the bacterial genomic DNA.