Table 4.

Serum cytokines altered during gingival infection with four periodontal bacteria.

		TLR2−/−		TLR4−/−
Type	Cytokine	Infected	Uninfected	Infected	Uninfected
Th1	IFNγ	2.05±0.30	2.68±1.3	2.06±0.92	1.96±0.26
	IL-1β	25.9±5.9	29.9±16	27.6±4.2	22.1±4.2
	IL-6	23.8±1.5	22.6±0.80	24.3±2.4	23.1±1.2
	IL-12p70	24.5±1.7	26.9±3.08	25.6±4.1	30.0±1.5
	IL-28	29.6±1.5	31.5±3.3	32.5±5.06	35.4±2.42
	TNFα	62.4±8.5	45.6±20.79	44.2±4.5	69.6±19
Th2	IL-2	16.0±1.1	15.8±0.53	16.6±0.58	16.1±1.7
	IL-4	100.1±7.4	99.4±13	105.2±29	108.6±8.9
	IL-5	85.7±0.14	85.3±1.0	87.1±2.9	86.7±0.81
	IL-10	24.6±0.71	24.8±1.7	26.1±1.5	27.6±1.2
	IL-28	29.6±1.5	31.5±3.3	32.5±5.06	35.4±2.42
	TGFβ1	7.59±0.32	7.18±0.74	7.56±0.32	7.94±0.37
	MIP-3α	38.9±3.28	41.10±5.2	33.9±1.8	31.8±1.3
	IL-13	4.8±0.099	4.82±0.09	5.00±0.26	4.84±0.03
Th17	IL-17	34.9±0.40	32.7±0.94	31.7±3.9	33.6±0.58
	IL-21	5.25±0.04	5.21±0.12	5.31±0.21	7.19±2.6
	IL-22	4.58±0.01	4.56±0.02	4.59±0.00	4.99±0.59
	IL-23	1.82±0.38	1.69±0.21	1.50±0.47	2.19±0.42

Values are mean x10 (pg/ml) ± SD x10 , n = 4 infected, n = 3 control.