Table 5.
Splenocyte cytokine concentration in TLR2−/− and TLR4−/− infected and sham-infected mice.
TLR2−/− | TLR4−/− | ||||
---|---|---|---|---|---|
Type | Cytokine | Infected | Uninfected | Infected | Uninfected |
Th1 | IFNγ | 1.8±0.42* | 1.1±0.13 | 1.54±0.12 | 1.74±0.25 |
IL-1β | 22.9±1.3 | 18.9±1.9 | 23.42±1.8 | 21.5±4.7 | |
IL-6 | 22.3±1.6 | 22.0±0.13 | 21.54±0.41 | 22.5±0.21 | |
IL-12p70 | 24.5±4.8 | 24.1±3.1 | 32.07±1.2 | 32.4±0.66 | |
IL-28 | 36.1±1.1 | 31.6±0.56 | 38.60±1.2 | 37.7±1.9 | |
TNFα | 49.4±6.6 | 34.8±8.5 | 43.70±.34 | 62.9±1.2 | |
Th2 | IL-2 | 17.8±1.5 | 14.6±1.9 | 15.47±0.69 | 15.3±0.68 |
IL-4 | 10.9±20 | 87.1±8.3 | 12.48±7.3 | 12.1±7.8 | |
IL-5 | 85.3±0.72 | 83.5±0.22 | 8.50±0.64 | 8.49±0.64 | |
IL-10 | 29.1±2.6 | 22.6±2.0 | 28.59±0.47 | 28.3±1.2 | |
IL-28 | 36.1±1.1 | 31.6±0.56 | 38.60±1.2 | 37.7±1.9 | |
TGFβ1 | 7.90±0.097* | 7.0±0.39 | 7.577±0.12 | 7.75±0.21 | |
MIP-3α | 30.7±0.28** | 28.7±0.25 | 30.57±0.074 | 29.7±0.42 | |
IL-13 | 4.99±0.057** | 4.75±0.0002 | 4.90±0.05 | 4.95±0.03 | |
Th17 | IL-17 | 35.7±1.07** | 31.4±2.1 | 31.78±0.82 | 32.9±0.51 |
IL-21 | 5.59±0.079** | 4.98±0.14 | 5.40±0.21 | 5.49±0.032 | |
IL-22 | 4.60±0.026* | 0.46±0.003 | 4.56±0.011 | 4.55±0.001 | |
IL-23 | 1.94±0.52* | 1.19±0.12 | 1.31±0.13 | 1.79±0.15 |
Values are mean x103(pg/ml) ± SD x103, n = 4 infected, n = 3 control.
p < 0.05 infected vs. control,
p < 0.01 infected vs. control.