Table 6.
Polymicrobial infection-induced aortic TLR signaling gene expression changes.
| TLR2−/− mice | TLR4−/− mice | ||||
|---|---|---|---|---|---|
| Genes | p-value | Fold change | Genes | p-value | Fold change |
|
|
|
||||
| Ccl2 | 0.3054 | 2.53 | Fos | 0.1158 | −3.28 |
| Chuk | 0.3037 | 3.65 | Hspa1a | 0.3813 | 2.51 |
| Clec4e | 0.3732 | 4.37 | Ifng | 0.1007 | −2.56 |
| Csf2 | 0.2618 | 3.51 | Il-1α | 0.3490 | −5.36 |
| Fos | 0.1637 | 3.61 | Il-6 | 0.0001 | −2.78 |
| Hmgb1 | 0.3351 | 3.12 | Il-12α | 0.0583 | −4.79 |
| Hspa1a | 0.3604 | 6.72 | Hspd1 | 0.0390 | 1.46 |
| Ifnb1 | 0.3725 | 4.32 | Il2 | 0.0253 | −1.76 |
| Il-1β | 0.3698 | 3.04 | Jun | 0.0023 | −2.22 |
| Il-2 | 0.3762 | 2.59 | |||
| Il-6 | 0.3710 | 4.51 | |||
| Il-10 | 0.3802 | 3.04 | |||
| Lta | 0.5684 | −3.00 | |||
| Mapk8 | 0.3011 | 3.41 | |||
| Muc13 | 0.3784 | 3.98 | |||
| Myd88 | 0.3801 | 2.60 | |||
| Ptgs2 | 0.3748 | 3.69 | |||
| Ube2v1 | 0.3785 | 3.28 | |||
Polymicrobial-infected and sham-infected control TLR2−/− and TLR4−/− mouse aortic tissue samples were processed and analyzed as described in methods. Bold letters indicate genes significantly altered in TLR4−/− mice.