Skip to main content
. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Magn Reson Med. 2016 May 25;77(5):2005–2014. doi: 10.1002/mrm.26278

Figure 1.

Figure 1

Substrates for γ-glutamyl transferase (GGT). (a) The natural metabolite glutathione is cleaved by GGT to produce glutamate and a cysteine-glycine dipeptide. (b) A florescence agent, gGlu-HMRG, is activated after the glutamyl ligand is cleaved via GGT catalysis. (c) The proposed mechanism for GGT cleavage of the CEST MRI contrast agent, based on reference 16.