Fig. 8.

The effect of BzATP on ERG oscillatory potentials. Experiments were done in physiological Krebs medium. a Mean ± SEM percentage of control peak power; n = 7. BzATP (300 μM; 10 min) caused a reversible and significant reduction in the peak power output of the oscillatory potentials compared to control (P < 0.05), indicating modulation of inner retinal function. b(i) Representative oscillatory potentials, before, during and post-BzATP application. Black, control; blue, BzATP; grey, wash. Under control conditions, the oscillatory potentials exhibited a peak frequency ∼107 Hz, typical of dark-adapted ERG responses. In the presence of BzATP, no overall shift in frequency was detected. b(ii) Power Spectra (120 s) illustrate the BzATP-mediated suppression of the oscillatory potentials and recovery on washout. Black control; blue, BzATP; grey, wash. c A438079 (10 μM) significantly reduced the BzATP-evoked suppression of the oscillatory potentials compared to control. *P < 0.05, compared to pre-treatment control