Table 2.
Daily insulin doses for the modified intention-to-treat analysis population with last observation carried forward for missing observations at Week 24
| Insulin glargine | NPH insulin | |||||
|---|---|---|---|---|---|---|
| n | Mean ± SD | Median | n | Mean ± SD | Median | |
| (Q1, Q3) | (Q1, Q3) | |||||
| Mean daily total insulin, units/kg/day ± SDa | ||||||
| Baseline | 107 | 0.84 ± 0.23 | 0.82 (0.67, 1.00) | 53 | 0.87 ± 0.29 | 0.82 (0.70, 1.05) |
| Week 24 | 106 | 0.91 ± 0.25 | 0.91 (0.73, 1.04) | 50 | 1.08 ± 0.32 | 1.11 (0.86, 1.28) |
| Changeb | 106 | 0.08 ± 0.16 | 0.07 (–0.02, 0.17) | 50 | 0.19 ± 0.26 | 0.18 (–0.00, 0.35) |
| Week 24 (LOCF) | 107 | 0.91 ± 0.25 | 0.91 (0.73, 1.04) | 53 | 1.06 ± 0.32 | 1.06 (0.85, 1.26) |
| Change (LOCF)b | 107 | 0.07 ± 0.16 | 0.07 (–0.03, 0.17) | 53 | 0.19 ± 0.26 | 0.16 (–0.00, 0.35) |
| LS Mean Difference | −0.13 (0.03) | |||||
| 95% CI | −0.19 to –0.06 | |||||
| Mean daily basal insulin, units/kg/day ± SDa | ||||||
| Baseline | 107 | 0.29 ± 0.09 | 0.28 (0.23, 0.34) | 53 | 0.31 ± 0.13 | 0.32 (0.23, 0.38) |
| Week 24 | 106 | 0.31 ± 0.09 | 0.29 (0.25, 0.37) | 50 | 0.44 ± 0.16 | 0.44 (0.34, 0.52) |
| Changeb | 106 | 0.03 ± 0.07 | 0.02 (–0.01, 0.06) | 50 | 0.12 ± 0.14 | 0.11 (0.04, 0.20) |
| Week 24 (LOCF) | 107 | 0.31 ± 0.09 | 0.29 (0.25, 0.38) | 53 | 0.43 ± 0.16 | 0.43 (0.30, 0.50) |
| Change (LOCF)b | 107 | 0.02 ± 0.07 | 0.02 (–0.01, 0.06) | 53 | 0.11 ± 0.14 | 0.11 (0.04, 0.20) |
| LS Mean Difference | −0.01 (0.02) | |||||
| 95% CI | −0.13 to –0.06 | |||||
| Mean daily bolus insulin, units/kg/day ± SD | ||||||
| Baseline | 107 | 0.55 ± 0.18 | 0.53 (0.42, 0.68) | 52 | 0.58 ± 0.23 | 0.54 (0.40, 0.73) |
| Week 24 | 106 | 0.60 ± 0.19 | 0.58 (0.48, 0.71) | 49 | 0.64 ± 0.23 | 0.63 (0.46, 0.81) |
| Changeb | 106 | 0.05 ± 0.12 | 0.04 (–0.02, 0.10) | 49 | 0.06 ± 0.17 | 0.06 (–0.07, 0.18) |
| Week 24 (LOCF) | 107 | 0.60 ± 0.19 | 0.57 (0.47, 0.71) | 52 | 0.63 ± 0.23 | 0.63 (0.45, 0.81) |
| Change (LOCF)b | 107 | 0.05 ± 0.12 | 0.04 (–0.03, 0.10) | 52 | 0.06 ± 0.17 | 0.06 (–0.06, 0.18) |
| LS Mean Difference | −0.02 (0.02) | |||||
| 95% CI | −0.06 to 0.03 | |||||
aCalculated as the weekly average
bChange from baseline to Week 24
LS least square, Q1 quartile 1, Q3 quartile 3, SD standard deviation