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. 2016 Nov 25;17:975. doi: 10.1186/s12864-016-3307-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Genes in nutrient signaling networks require microbiota for structured coexpression. Modules exhibiting microbiota-dependent structure included genes with key roles in the IIS/TOR/AMPK nutrient signaling network. Pairwise coexpression (Spearman's Rho) of genes in the IIS/TOR/AMPK network [38, 39] is presented, for genes in differentially coexpressed modules. FoxO was not clustered into a DC module, but is plotted in the figure since it is the major transcriptional output of IIS. Numbers in each cell represent correlation coefficients. The figure demonstrates that the microbiota affects the regulation of these networks at the level of structured gene coexpression