Table 2.
Clinical and parasitological characteristics at day 2
| Day 2 (n = 64) | P value | ||
|---|---|---|---|
| PPR | PNR | ||
| n (%) | 8 (12.5%) | 56 (87.5%) | |
| Age (years) Median (IQR) |
7.5 (5–14.3) | 12 (6–22) | 0.236a |
| <8 years n (%) |
4 (50%) | 19 (33.9%) | 0.893b |
| 8–15 years n (%) |
2 (25%) | 15 (26.8%) | |
| >15 years n (%) |
2 (25%) | 22 (39.3%) | |
| Weight (kg) Median (IQR) |
26 (18–58.3) | 39 (21–61) | 0.551a |
| P. falciparum density (parasites/µl) | |||
| Day 0 Median (IQR) |
81,260 (35,110–133,200) | 44,260 (17,720–87,300) | 0.150a |
| Day 2 Median (IQR) |
293 (145–736) | 0 | |
| Parasite decrease rate (%) Median (IQR) |
99.6 (98.9–99.8) | 100 | |
| Symptoms n (%) | |||
| Headache | 0 (0%) | 3 (5.3%) | 1.000c |
| Vomiting | 0 (0%) | 1 (1.8%) | 1.000c |
| Diarrhoea | 0 (0%) | 0 (0%) | 1.000c |
| Diffuse pain | 0 (0%) | 0 (0%) | 1.000c |
| Fever (≥38 °C) | 0 (0%) | 1 (1.8%) | 1.000c |
| Anti-malarial dose (mg/kg) | |||
| DHA | |||
| Median (IQR) | 2.4 (1.9–3.1) | 2.4 (2.0–2.9) | 0.570a |
| <25 kg | 2.5 (2.4–3.4) | 2.8 (2.4–3.4) | 0.891a |
| ≥25 kg | 2.3 (1.8–3.1) | 2.1 (1.8–2.6) | 0.425a |
| PPQ | |||
| Median (IQR) | 19.4 (15.5–24.6) | 18.8 (15.7–22.9) | 0.570a |
| <25 kg | 20.0 (18.8–03.5) | 22.1 (18.8–27.5) | 0.891a |
| ≥25 kg | 18.3 (14.1–24.6) | 17.1 (14.3–20.4) | 0.425a |
Day 2 PPR: proportion of patients remaining parasitaemic on day 2
Day 2 PNR: proportion of patients without parasitaemia on day 2
aMann–Whitney U test
bChi2 test
cFisher’s exact test