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. 2016 Nov 26;14:76. doi: 10.1186/s12951-016-0229-2

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Increased survival of ZNP/ZBP-ScaA immunized mice. Mice (n = 5/group) were immunized with ZNP, ZBP-ScaA, ZNP/ScaA, ZNP/ZBP-ScaA, and Alum/ZBP-ScaA three times at 2 weeks interval. One week after last immunization, mice were challenged with 100 × LD₅₀ of O. tsutsugamushi. Their survival was monitored until all the surviving mice recovered from the disease. *p < 0.05; **p < 0.01