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General scheme of the catalytic mechanism of serine β-lactamases. The β-lactam ring is shown in red. The serine nucleophile is activated via a general base and attacks the carbonyl of the β-lactam ring in the acylation step. This results in formation of the covalent acyl-enzyme complex. In the deacylation step the complex is resolved by a catalytic water molecule, which is activated by the general base.
