Supplementary Table 4.
KEGG pathway analysis based on highly expressed miRNA targets. Note that KEGG pathway enrichment is for lactation-related miRNA targets.
| A Pathway of down-regulated miRNA target. | |||
|---|---|---|---|
| GOID | GO term | No. genes | Term P Value Corrected with Bonferroni step down |
| KEGG: 04320 | Dorso-ventral axis formation | 10 | 2.15E-06 |
| KEGG: 04010 | MAPK signaling pathway | 26 | 2.28E-04 |
| KEGG: 05206 | MicroRNAs in cancer | 28 | 3.62E-04 |
| KEGG: 05214 | Glioma | 11 | 0.002349762 |
| KEGG: 05223 | Non-small cell lung cancer | 10 | 0.003465807 |
| KEGG: 04022 | cGMP-PKG signaling pathway | 18 | 0.0039885 |
| KEGG: 05205 | Proteoglycans in cancer | 20 | 0.005731077 |
| KEGG: 04012 | ErbB signaling pathway | 12 | 0.007906834 |
| KEGG: 05231 | Choline metabolism in cancer | 13 | 0.008142061 |
| KEGG: 05161 | Hepatitis B | 16 | 0.008760234 |
| KEGG: 04919 | Thyroid hormone signaling pathway | 14 | 0.011458475 |
| KEGG: 05230 | Central carbon metabolism in cancer | 10 | 0.016058162 |
| KEGG: 05200 | Pathways in cancer | 29 | 0.027849671 |
| KEGG: 05202 | Transcriptional misregulation in cancer | 17 | 0.029870001 |
| KEGG: 04150 | mTOR signaling pathway | 9 | 0.03240035 |
| KEGG: 05220 | Chronic myeloid leukemia | 10 | 0.032404467 |
| KEGG: 04930 | Type II diabetes mellitus | 8 | 0.033460878 |
| KEGG: 04961 | Endocrine and other factor-regulated calcium reabsorption | 8 | 0.033460878 |
| B Pathway of up-regulated miRNA target. | |||
|---|---|---|---|
| GOID | GO term | No. genes | Term P Value Corrected with Benjamini-Hochberg |
| KEGG: 04919 | Thyroid hormone signaling pathway | 19 | 5.93E-04 |
| KEGG: 05206 | MicroRNAs in cancer | 33 | 6.34E-04 |
| KEGG: 05205 | Proteoglycans in cancer | 26 | 6.38E-04 |
| KEGG: 04510 | Focal adhesion | 27 | 8.36E-04 |
| KEGG: 04360 | Axon guidance | 18 | 0.002137231 |
| KEGG: 04010 | MAPK signaling pathway | 28 | 0.002293612 |
| KEGG: 05202 | Transcriptional misregulation in cancer | 22 | 0.002612816 |
| KEGG: 05218 | Melanoma | 12 | 0.004135083 |
| KEGG: 04550 | Signaling pathways regulating pluripotency of stem cells | 18 | 0.004544666 |
| KEGG: 05211 | Renal cell carcinoma | 11 | 0.004565614 |
| KEGG: 05214 | Glioma | 11 | 0.004595295 |
| KEGG: 04012 | ErbB signaling pathway | 13 | 0.004598649 |
| KEGG: 05222 | Small cell lung cancer | 13 | 0.004778807 |
| KEGG: 05220 | Chronic myeloid leukemia | 12 | 0.004814658 |
| KEGG: 04151 | PI3K-Akt signaling pathway | 33 | 0.004894532 |
| KEGG: 04152 | AMPK signaling pathway | 16 | 0.005007425 |
| KEGG: 04810 | Regulation of actin cytoskeleton | 23 | 0.005099651 |
| KEGG: 04350 | TGF-beta signaling pathway | 12 | 0.005719938 |
| KEGG: 04710 | Circadian rhythm | 7 | 0.006234951 |
| KEGG: 04068 | FoxO signaling pathway | 16 | 0.009418922 |