Supplementary Table 3.
GO analysis based on highly expressed miRNA targets. Note that the biological process category is for lactation-related miRNA targets.
| A Biological process of down-regulated miRNA. | |||
|---|---|---|---|
| GO term | No. genes | Term P Value Corrected with Bonferroni step down | log2P |
| Positive regulation of macromolecule metabolic process | 182 | 8.32E-17 | 16.07996775 |
| Positive regulation of cellular metabolic process | 185 | 8.43E-15 | 14.07396225 |
| Nervous system development | 155 | 8.56E-15 | 14.06754556 |
| Positive regulation of macromolecule biosynthetic process | 122 | 2.44E-14 | 13.61261041 |
| Positive regulation of cellular biosynthetic process | 127 | 1.83E-13 | 12.7382415 |
| Positive regulation of biosynthetic process | 128 | 2.52E-13 | 12.59793599 |
| Positive regulation of nucleobase-containing compound metabolic process | 121 | 9.15E-13 | 12.03834877 |
| Positive regulation of gene expression | 121 | 1.27E-12 | 11.89715016 |
| Positive regulation of transcription, DNA-templated | 107 | 1.30E-12 | 11.88737081 |
| Positive regulation of nucleic acid-templated transcription | 107 | 1.30E-12 | 11.88737081 |
| Positive regulation of nitrogen compound metabolic process | 122 | 1.60E-12 | 11.79704508 |
| Positive regulation of RNA metabolic process | 109 | 4.62E-12 | 11.33535686 |
| Positive regulation of RNA biosynthetic process | 107 | 5.30E-12 | 11.27612632 |
| Regulation of macromolecule biosynthetic process | 227 | 1.07E-11 | 10.97066187 |
| Regulation of nucleobase-containing compound metabolic process | 227 | 1.83E-11 | 10.73639878 |
| B Biological process of up-regulated miRNA. | |||
|---|---|---|---|
| GO Term | No. genes | Term P Value Corrected with Bonferroni step down | log2P |
| Multicellular organismal development | 353 | 5.03E-20 | 19.29808555 |
| Regulation of macromolecule metabolic process | 396 | 6.22E-20 | 19.20595298 |
| Negative regulation of biological process | 334 | 6.74E-20 | 19.17123925 |
| Positive regulation of macromolecule metabolic process | 229 | 4.55E-19 | 18.34163176 |
| Regulation of metabolic process | 446 | 1.54E-18 | 17.81317793 |
| Negative regulation of cellular process | 310 | 1.59E-18 | 17.79753238 |
| System development | 315 | 1.02E-17 | 16.99352731 |
| Regulation of cellular metabolic process | 402 | 1.69E-17 | 16.7718758 |
| Regulation of macromolecule biosynthetic process | 302 | 2.86E-17 | 16.54383494 |
| Regulation of primary metabolic process | 388 | 3.66E-17 | 16.43665168 |
| Regulation of cellular macromolecule biosynthetic process | 294 | 1.13E-16 | 15.94714185 |
| Positive regulation of metabolic process | 271 | 1.37E-16 | 15.86279658 |
| Positive regulation of macromolecule biosynthetic process | 153 | 1.60E-16 | 15.79720478 |
| Regulation of biosynthetic process | 312 | 2.16E-16 | 15.66486045 |
| Regulation of cellular biosynthetic process | 309 | 4.09E-16 | 15.38825063 |