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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Neuroimage. 2016 Aug 26;143:82–90. doi: 10.1016/j.neuroimage.2016.08.040

Fig. 3. 2DG dose dependency.

Fig. 3

Time courses of the CESL R1ρ change (A) obtained from the rat cortex for three 2DG doses of 0.25 (n=4 animals), 0.5 (n=6) and 1 g/kg (n=7). Animals were maintained under 1.5% isoflurane. (B) Dose-dependent R1ρ changes in 5 to 30 min, 31 to 60 min, and 61 to 90 min periods. The R1ρ change is linearly dependent on the injection dose at an early time, but not later time. This suggests that the early response is sensitive to 2DG transport while the later time is more weighted to metabolized 2DG6P. Error bars: SD.