Table 2.

Concentrations of Immune Mediators at Each Visit

Immune Mediator	Enrollment*	Return Visit 1*	Return Visit 2*	Return Visit 3*
Median (Range), pg/mL	n=76	n=67	n=58	n=16
Elafin
Pregnant	879 (173 – 4241)	581 (140 – 4457)	631 (144 – 3872)	769 (176 – 7535)
Non Pregnant	1215 (182 – 14661)	958 (210 – 8308)	1138 (197 – 5072)
P value	0.2	0.4	0.06
HBD-2
Pregnant	1292 (428 – 5828)	1361 (291 – 7411)	1077 (189 – 9999)	1455 (234 – 5896)
Non Pregnant	1758 (8 – 14298)	1914.50 (512 – 16246)	1840 (462 – 7596)
P value	0.3	0.03	0.03a
HBD-3
Pregnant	89 (6 – 2000)	51 (6 – 264)	38 (5 – 563)	6 (6 – 171)
Non Pregnant	39 (6 – 484)	85 (5 – 1884)	95 (6 – 414)
P value	0.1	0.1	0.04
Lactoferrin
Pregnant	51 (7 – 3239)	40 (12 – 4209)	26 (12 – 7318)	56 (12 – 853)
Non Pregnant	73 (8 – 697)	79 (8 – 1000)	101 (12 – 1766)
P value	0.2	0.05	0.001a
LL-37
Pregnant	88 (12 – 3396)	74 (12 – 1757)	53 (12 – 3563)	89 (12 – 1382)
Non Pregnant	77 (12 – 1502)	99 (12 – 810)	168 (12 – 1611)
P value	0.7	0.3	0.003a
MIP-3α
Pregnant	8 (5 – 68)	8 (6 – 73)	8 (6 – 37)	8 (6 – 83)
Non Pregnant	8 (7 – 741)	8 (5 – 1424)	8 (6 – 401)
P value	0.001a	0.05	0.006a
RANTES
Pregnant	6 (6 – 47)	6 (4 – 60)	6 (5 – 103)	6 (4 – 57)
Non Pregnant	6 (6 – 1063)	6 (6 – 242)	6 (4 – 54)
P value	0.06	0.04	0.03
SDF-1
Pregnant	13 (3 – 152)	12 (4 – 174)	9 (4 – 449)	15 (3 – 183)
Non Pregnant	14.50 (4 – 378)	24 (3 – 2000)	36 (4 – 873)
P value	0.6	0.04	0.003a
SLPI
Pregnant	768 (181 – 14222)	960 (100 – 15786)	1328 (142 – 15444)	1152 (115 – 8574)
Non Pregnant	1501 (69 – 14144)	1360 (278 – 16000)	1585 (178 – 11212)
P value	0.2	0.1	0.4

All p-values by Wilcoxon rank sum test

^aStatistically significant controlling for a false discovery rate of 5% for each time point.

^*

• Pregnancy visits: Enrollment- <14 weeks gestation
  Return visit 1- 14–28 weeks gestation
  Return visit 2- >28 weeks gestation
• Non-pregnant visits: Enrollment- Proliferative phase
  Return visit 1- Ovulatory phase
  Return visit 2- Secretory phase