. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: IEEE J Biomed Health Inform. 2016 May 27;20(5):1225–1231. doi: 10.1109/JBHI.2016.2574201

TABLE I.

Performance Comparison Based on the Optimal Number of Features Selected in the TU Cohort

TU Cohort	Glycomic		Proteomic	Integrated (P & G)
Accuracy	0.77		0.84	0.87

Sensitivity	0.82		0.83	0.90

Specificity	0.75		0.84	0.85

AUC (95% CI)	0.87 (0.78, 0.93)		0.93 (0.83, 0.97)	0.92 (0.81, 0.97)

Optimal Number of Features	29/82		15/101	9/183

Selected Features^b	[25000]	[43000]^a	P01024 ^a
	[53111]^a	[34100]^a	P02743
	[63402]^a	[43202]^a,^c	P02750
	[53313]	[53000]^a	P02753 ^a	P02743
	[53323]	[33101]	P02763	P02763
	[34110]	[63403]^a	P03952	P05160
	[53311]^c	[53311]^c	P04004 ^a	P06727
	[43110]^a	[53010]	P05160	P0C0L4
	[63413]^a	[53302]^a	P06727	P22891^a
	[53411]	[34101]	P0C0L4	P35858
	[63423]	[63404]^a	P13598 ^a	[43000]^a
	[53312]	[29000]	P13796	[26000]
	[53101]^a	[73514]	P22891 ^a
	[53201]	[43202]^a,^c	P27918
	[2 10 000]		P35858

Significant (p value ≤ 0.05) in univariate statistical analysis

N-glycans are characterized by GlcNAc, mannose, galactose, fucose, and NeuNAc, and proteins are indicated by Uniprot IDs

Isomers with different retention times

The results of best performing methods are marked in bold.