Table 6.

Analyses of covariance comparing DBP values of untreated (not taking antihypertensive medications) PWH and NHANES subjects after adjusting for age and each covariate.

Covariate	Regression coefficient for Z (PWH versus NHANES)			r 2
	b	95% CI	P
Young adults (18–29 years)
No covariates (Cage + Cage 2 + Z only)	9.03	6.80, 11.25	<0.001	0.113
log BMI	8.59	6.80, 10.38	<0.001	0.167
log (1 + Creatinine)	8.91	7.06, 10.76	<0.001	0.159
eGFR	8.92	7.08, 10.77	<0.001	0.159
log TotalCholesterol	8.97	6.66, 11.28	<0.001	0.123
Smoking status	8.28	6.13, 10.43	<0.001	0.121
HCV	8.18	6.01, 10.35	<0.001	0.156
Race	8.52	6.77, 10.27	<0.001	0.162
All covariates∗	10.38	7.43, 13.33	<0.001	0.163
Older adults (30–79 years)
No covariates (Cage + Cage 2 + Z only)	2.99	1.21, 4.77	0.001	0.035
log BMI	4.54	3.04, 6.03	<0.001	0.083
log (1 + Creatinine)	4.18	2.62, 5.73	<0.001	0.049
eGFR	4.10	2.54, 5.65	<0.001	0.047
log TotalCholesterol	4.03	2.14, 5.91	<0.001	0.050
Smoking status	3.15	1.43, 4.87	<0.001	0.039
HCV	2.45	−0.14, 5.04	0.064	0.045
Race	†			0.062
All covariates∗	†			0.121
All covariates except HCV∗	†			0.116

Z  indicates the binary variable that distinguishes PWH from NHANES (Z = 1 for PWH, Z = 0 for NHANES); PWH, patients with hemophilia; NHANES, subjects from the National Health and Nutrition Examination Survey of the general United States population; b, regression coefficient for Z representing change in log SBP per unit increase of the selected covariate; CI, confidence interval; r ², square of the multiple correlation coefficient; BMI, body mass index; eGFR, estimated glomerular filtration rate; HCV, hepatitis C virus.

^∗ Cage, Cage ², log BMI, eGFR, log TotalCholesterol, smoking status, HCV, and race.

^† Z∗race interaction was significant and therefore ANCOVA cannot be performed.