Table 2.
Effect of dosage on HIV inhibition of macrophages using GPs containing gallium carbonate at different loading levels of gallium. Results are the average of three experiments. Statistical significance was determined by t-test, a P < 0.05 statistical significance between GP-Ga2(CO3)3 and GP control, and b P < 0.1 statistical significance between dosing regimes.
Sample | µg Ga/mg GP | % HIV inhibition ± SD | |
---|---|---|---|
Day −1 dose | Days −1, 1, 3 doses | ||
GP | 0 | 10 ± 9 | 19 ± 16 |
GP-Ga2(CO3)3 | 108 | 45 ± 2a | 74 ± 17a |
GP-Ga2(CO3)3 | 150 | 53 ± 19 | 92 ± 3a |
GP-Ga2(CO3)3 | 355 | 44 ± 19 | 91 ± 2a,b |