Table 1.
Summary of effects produced by different FFAs on the nAChR (Perillo et al., 2012).
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| Petroselenic acid (18:1 cis-6) | Oleic acid (18:1 cis-9) | Vaccenic acid (18:1 cis-11) | Octadecanoic acid (18:1 cis-13) | Elaidic acid (18:1 trans-9) | |
| Sites at lipid-nAChR interface | Aa | A + NAb | A + NA | A + NA | A + NA |
| inhibition of nAChR function | + | ++ | – | – | – |
| GP modification | ++ | +++ | ++ | + | – |
| Anisotropy modification | + | +++ | ++ | ++ | – |
| nAChR TM4 perturbation | + | ++ | ++ | ++ | – |
| R-state perturbation | – | ++ | ++ | ++ | – |
| D-state perturbation | ++ | ++ | + | + | + |
The CPK structures of the FFAs studied are shown for clarity: the broken line shows the position of the cis double bond and the arrow indicates the position of the trans double bond.
a
A, annular sites;
b
NA, non-annular sites.